OUR FACILITIESOUR CDMO

Make your life simple
One partner for every step of your program
bt_bb_section_bottom_section_coverage_image

PROCESS DEVELOPMENT

Microbiotic candidates

Aerobic & anaerobic
Consortia & multi or single-strains
Commensal and delivery GMO
Post-biotic

R&D Microbiology Platform

Risk group assessment (Bioinformatics)
Strain Isolation & characterization: Screening,
Strain-specific ID (Molecular tools), Strain characterization
Analytical methods transfer development & validation

R&D Process Platform

Manufacturability screening and process development
Fermenters: 0.5L, 2L, 5L, 20L, 150L
Centrifugation & TFF
Freeze-driers : 2 x 0.5m² – 1.5m² – 4m²
Dosage form: Capsule, tablet, sticks, oil-suspension, cream
Powder & Product characterization
Comparability tests

humility

efficiency

expertise

agility

https://www.biose.com/wp-content/uploads/2021/05/biose-gelule-microbiom.jpg
https://www.biose.com/wp-content/uploads/2021/05/biose-gelule-microbiom-aurillac.jpg
https://www.biose.com/wp-content/uploads/2021/05/biose-gelule-microbiom-aurillac-cdmo.jpg

GMP DRUG SUBSTANCE

Cell banking

GMP MCB and WCB manufacturing
according to LBP Guidelines
and storage at -80°c & -20°c

Scale-up & manufacturing

DS1 : 300L and 3 500L – Centrifugation & TFF + 25m² freeze-dryer
DS2 : 2 000L – dedicated Lcr35 – Concentration + 6m² freeze-dryer
DS3 : 4 x 800L – dedicated Lcr35 – 2x 30m² freeze-dryer
DS4 : 150L – Centrifugation + 1m² freeze-dryer
DS5 : 2 000L – Centrifugation + 12m² freeze-dryer
DS6 : 5 000L – Centrifugation + 30m² freeze-dryer
Commercial or clinical batches released by our QP (PharmD)
Powder placebo production for Capsule & Tablet & Sachet

35 M€ investment over
the next 4 years to maintain
our position as the world
leading CDMO for LBPs

https://www.biose.com/wp-content/uploads/2021/05/biose-microbiotic.jpg

35 M€ investment over

the next 4 years to maintain

our position as the world

leading CDMO for LBPs

GMP DRUG PRODUCT

Candidates strains

Aerobic & anaerobic
Consortia & single strains
Commensal and GMO organisms

Scale-up & manufacturing

Formulation & Excipient screening and placebo
formulation for Capsules/ Tablets/Sachets /
Oils & Creams
Blending from 10 to 400 kg
Dosage forms : Capsules, Tablets, Powder
Enteric Banding and Coating
Packaging : Blisters, Vials, Sachets,
Tubes, Creams & Oils.

In 2020

55 tonnes of DS
100 million capsules
10 million sticks

Many clinical batches for Europe and US

bt_bb_section_top_section_coverage_image